Kune, S., G.A. Kune, L.F. Watson, 1987. Case-control study of dietary etiological factors: the Melbourne colorectal cancer study. Nutr Cancer. 9:21-42.
A brief description is given of a large and comprehensive population-based investigation of colorectal cancer with a new study design. The study design allows the simultaneous examination of the incidence pattern, all the hypothesized causes and all the survival determinants of colorectal cancer of a defined population in a single data set. The relevance of this approach to surgeons in the primary prevention of and screening for colorectal cancer is illustrated in relation to the findings. Thus a diet with a low intake of fat and red meat and high intake of plant foods seems the most important factor in the primary prevention of colorectal cancer. In the screening for this cancer, high-risk groups include those with a previous colorectal cancer, a previous adenomatous polyp, a family history of colorectal cancer in first-degree relatives, Jews, those with an unsatisfactory diet and for rectal cancer, also those who are heavy beer consumers.
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