S. Perna, A. Giacosa, G. Bonitta, C. Bologna, A. Isu, D. Guido, M. Rondanelli, 2016. Effects of hazelnut consumption on blood lipids and body weight: A systematic review and Bayesian meta-analysis. Nutrients. 8,747; doi:10.3390/nu8120747.
Hazelnuts are rich in monounsaturated fatty acids and antioxidant bioactive substances: their consumption has been associated with a decreased risk of cardiovascular disease events. A systematic review and a meta-analysis was performed to combine the results from several trials and to estimate the pooled (overall) effect of hazelnuts on blood lipids and body weight outcomes. Specifically, a Bayesian random effect meta-analysis of mean differences of ∆-changes from baseline across treatment (MD∆) (i.e., hazelnut-enriched diet vs. control diet) has been conducted. Nine studies representing 425 participants were included in the analysis. The intervention diet lasted 28–84 days with a dosage of hazelnuts ranging from 29 to 69 g/day. Out of nine studies, three randomized studies have been meta-analyzed showing a significant reduction in low-density lipoprotein (LDL) cholesterol (pooled MD∆ = −0.150 mmol/L; 95% highest posterior density interval (95% HPD) = −0.308; −0.003) in favor of a hazelnut-enriched diet. Total cholesterol showed a marked trend toward a decrease (pooled MD∆ = −0.127 mmol/L; 95% HPD = −0.284; 0.014) and high-density lipoprotein (HDL) cholesterol remained substantially stable (pooled MD∆ = 0.002 mmol/L; 95% HPD = −0.140; 0.147). No effects on triglycerides (pooled MD∆ = 0.045 mmol/L; 95% HPD = −0.195; 0.269) and body mass index (BMI) (pooled MD∆ = 0.062 kg/m2 ; 95% HPD = −0.293; 0.469) were found. Hazelnut-enriched diet is associated with a decrease of LDL and total cholesterol, while HDL cholesterol, triglycerides and BMI remain substantially unchanged.
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